Anti-proteasome 20S subunit alpha 8 antibodies are used for the immunodetection of the protein encoded by the PSMA8 gene. In humans, the canonical protein has a reported length of 256 amino acid residues and a mass of 28.5 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of the Peptidase T1A protein family, it is a known component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Other names for this target antigen include alpha4s, proteasome (prosome, macropain) subunit, alpha type, 8, proteasome alpha 4 subunit, proteasome subunit alpha 8, and proteasome subunit alpha-type 8. Gene orthologs have been identified in the mouse, rat, bovine and chimpanzee species.