Anti-DNA replication fork stabilization factor DONSON antibodies are used for the immunodetection of the protein encoded by the DONSON gene. In humans, the canonical protein has a reported length of 566 amino acid residues and a mass of 62.7 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 3 different isoforms for this protein. It is reported to be expressed in the brain, with higher levels in prenatal compared to adult brain. A member of the DONSON protein family, it is reported to be a replisome component that maintains genome stability by protecting stalled or damaged replication forks. The gene encoding this protein is implicated in Microcephaly-micromelia syndrome. Other names for this target antigen include C21orf60, MIMIS, MISSLA, protein downstream neighbor of Son, downstream neighbor of SON, and B17. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.