Anti-tRNA methyltransferase activator subunit 11-2 antibodies are used for the immunodetection of the protein encoded by the TRMT112 gene. In humans, the canonical protein has a reported length of 125 amino acid residues and a mass of 14.2 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the TRM112 protein family, it is known to act as a activator of both rRNA/tRNA and protein methyltransferases. Other names for this target antigen include HSPC170, TRM112, hTrm112, multifunctional methyltransferase subunit TRM112-like protein, TRM112-like protein, and HSPC152. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish and chimpanzee species.