Anti-PML nuclear body scaffold antibodies are used for the immunodetection of the protein encoded by the PML gene. In humans, the canonical protein has a reported length of 882 amino acid residues and a mass of 97.6 kDa. Its subcellular localization is in the membrane, nucleus, ER, and cytoplasm. Alternative splicing is reported to yield 12 different isoforms for this protein. It is reported to function via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Post-translational modifications have been described, including ubiquitination, acetylation and phosphorylation. Other names for this target antigen include PP8675, RNF71, TRIM19, protein PML, E3 SUMO-protein ligase PML, PML/RARA fusion, RING finger protein 71, and MYL. Gene orthologs have been identified in the mouse, rat, bovine, chimpanzee and chicken species.