Anti-tryptophanyl-tRNA synthetase 1 antibodies are used for the immunodetection of the protein encoded by the WARS1 gene. In humans, the canonical protein has a reported length of 471 amino acid residues and a mass of 53.2 kDa. Its subcellular localization is in the cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Class-I aminoacyl-tRNA synthetase protein family, it is known to be involved with angiogenesis and the regulation of cell proliferation. Post-translational modifications have been described, including protein cleavage. The gene encoding this protein is implicated in Neuronopathy. Other names for this target antigen include HMN9, IFI53, IFP53, NEDMSBA, WARS, and GAMMA-2. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.