Anti-SRY-box transcription factor 8 antibodies are used for the immunodetection of the protein encoded by the SOX8 gene. In humans, the canonical protein has a reported length of 446 amino acid residues and a mass of 47.3 kDa. Its subcellular localization is in the nucleus. It is reported to be a transcription factor that may play a role in central nervous system, limb and facial development. Other names for this target antigen include SRY (sex determining region Y)-box 8, SRY-box 8, and transcription factor SOX-8. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.