Anti-SEC61 translocon subunit alpha 1 antibodies are used for the immunodetection of the protein encoded by the SEC61A1 gene. In humans, the canonical protein has a reported length of 476 amino acid residues and a mass of 52.3 kDa. Its subcellular localization is in the ER. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be expressed in proximal and distal tubules in the kidney. A member of the SecY/SEC61-alpha protein family, it is known to be a component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). The gene encoding this protein is implicated in Tubulointerstitial kidney disease. Other names for this target antigen include HNFJ4, HSEC61, SEC61, SEC61A, protein transport protein Sec61 subunit alpha isoform 1, and ADTKD5. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.