Anti-geminin DNA replication inhibitor antibodies are used for the immunodetection of the protein encoded by the GMNN gene. In humans, the canonical protein has a reported length of 209 amino acid residues and a mass of 23.6 kDa. Its subcellular localization is in the nucleus and cytoplasm. A member of the Geminin protein family, it is reported to inhibit DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). Post-translational modifications have been described, including phosphorylation. The gene encoding this protein is implicated in Meier-Gorlin syndrome. Other names for this target antigen include MGORS6, geminin, and Gem. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.