Anti-adenosine deaminase RNA specific B1 antibodies are used for the immunodetection of the protein encoded by the ADARB1 gene. In humans, the canonical protein has a reported length of 741 amino acid residues and a mass of 80.8 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 6 different isoforms for this protein. It is reported to be highly expressed in the brain and heart and at lower levels in the placenta. It is known to catalyze the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. The gene encoding this protein is implicated in Neurodevelopmental disorder with hypotonia, microcephaly, and seizures. Other names for this target antigen include DRABA2, DRADA2, NEDHYMS, RED1, double-stranded RNA-specific editase 1, and ADAR2. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.