Anti-methyltransferase 2B, methylcytidine antibodies are used for the immunodetection of the protein encoded by the METTL2B gene. In humans, the canonical protein has a reported length of 378 amino acid residues and a mass of 43.4 kDa. Its subcellular localization is in the cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the METL protein family, it is reported to be a S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). Other names for this target antigen include methyltransferase like 2B, methyltransferase-like protein 2B, and tRNA N(3)-methylcytidine methyltransferase METTL2B. Gene orthologs have been identified in the mouse, rat and chimpanzee species.