Anti-CXADR Ig-like cell adhesion molecule antibodies are used for the immunodetection of the protein encoded by the CXADR gene. In humans, the canonical protein has a reported length of 365 amino acid residues and a mass of 40 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 7 different isoforms for this protein. It is reported to be expressed in the pancreas, brain, heart, small intestine, testis, prostate and at a lower level in the liver and lung. It is a known component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Post-translational modifications have been described, including N-glycosylation and palmitoylation. Other names for this target antigen include CAR4/6, HCAR, coxsackievirus and adenovirus receptor, 46 kD coxsackievirus and adenovirus receptor (CAR) protein, CVB3-binding protein, and CAR. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.