Anti-methyltransferase 16, N6-methyladenosine antibodies are used for the immunodetection of the protein encoded by the METTL16 gene. In humans, the canonical protein has a reported length of 562 amino acid residues and a mass of 63.6 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the METTL16/RlmF protein family, it is reported to be a RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Other names for this target antigen include N6-adenosine-methyltransferase METTL16, N6-methyladenosine methyltransferase, U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase, and RNA N6-adenosine-methyltransferase METTL16. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.