Anti-LACTOPEROXIDASE antibodies are used for the immunodetection of the protein encoded by the LPO gene. In humans, the canonical protein has a reported length of 712 amino acid residues and a mass of 80.3 kDa. Its subcellular localization is in the cytoplasm and is secreted. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Peroxidase protein family, it is reported to be a heme-containing oxidoreductase, which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2) (By similarity). Post-translational modifications have been described, including glycosylation.
The lactoperoxidase marker can be used to characterize Bronchus Submucosal Gland Myoepithelial Cells Serous Secreting Cells, Bronchus Serous Cells, and Trachea Serous Cells.* Other names for this target antigen include SPO and salivary peroxidase. Gene orthologs have been identified in the mouse, rat, bovine and chimpanzee species. A number of LACTOPEROXIDASE antibodies have been mentioned in research publications and have associated citations. These antibodies are most commonly used in Western Blot experiments, among other applications.
*HuBMAP Human Reference Atlas v1.4