Anti-MTREX antibodies are used in the immunodetection of the protein Mtr4 exosome RNA helicase. In humans, the canonical protein has a reported length of 1042 amino acid residues and a mass of 117.8 kDa. Its subcellular localization is in the nucleus. It is notably widely expressed in many tissue types. A member of the Helicase protein family, MTREX is known to catalyze the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension. Synonyms for this target antigen include KIAA0052, Mtr4, SKIV2L2, fSAP118, exosome RNA helicase MTR4, and Dob1. MTREX gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.