Anti-GDF5 antibodies are used in the immunodetection of the protein growth differentiation factor 5. In humans, the canonical protein has a reported length of 501 amino acid residues and a mass of 55.4 kDa. Its subcellular localization is in the cell membrane and is also secreted. It is reported to be highly expressed in the long bones during embryonic development. A member of a the TGF-beta protein family, GDF5 is known to be a growth factor involved in bone and cartilage formation. Post-translational modifications have been described, including glycosylation. Synonyms for this target antigen include BMP-14, BMP14, CDMP1, DUPANS, LAP-4, LAP4, OS5, and BDA1C.