Anti-Cbl proto-oncogene B antibodies are used in the immunodetection of the protein encoded by the CBLB gene. In humans, the canonical protein has a reported length of 982 amino acid residues and a mass of 109.5 kDa. Its subcellular localization is in the cytoplasm. Alternative splicing is reported to yield 3 different isoforms for this protein. The Cbl proto-oncogene B protein is involved with immune response pathways and intracellular signal transduction, among other functions. Post-translational modifications have been described, including ubiquitination and phosphorylation. Other names for this target antigen include RNF56, E3 ubiquitin-protein ligase CBL-B, Cas-Br-M (murine) ecotropic retroviral transforming sequence b, Cbl proto-oncogene B, E3 ubiquitin protein ligase, and Nbla00127.