Anti-PR/SET domain 1 antibodies are used in the immunodetection of the protein encoded by the PRDM1 gene. In humans, the canonical protein has a reported length of 825 amino acid residues and a mass of 91.8 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of the Class V-like SAM-binding methyltransferase protein superfamily, it is reported to be a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Post-translational modifications have been described, including ubiquitination, sumoylation. Other names for this target antigen include PRDI-BF1, PR domain zinc finger protein 1, B-lymphocyte-induced maturation protein 1, BLIMP-1, PR domain 1, and BLIMP1.