Anti-SPOP antibodies are used in the immunodetection of the protein speckle type BTB/POZ protein. In humans, the canonical protein has a reported length of 374 amino acid residues and a mass of 42.1 kDa. Its subcellular localization is in the nucleus. It is widely expressed across many tissue types. A member of the Tdpoz protein family, SPOP is a known component of the cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. The SPOP gene has been associated with the disease, Nabais Sa-de Vries syndrome. Synonyms for this target antigen include NEDMACE, NEDMIDF, NSDVS1, NSDVS2, TEF2, speckle-type POZ protein, HIB homolog 1, and BTBD32. SPOP gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.