Anti-rhomboid 5 homolog 2 antibodies are used for the immunodetection of the protein encoded by the RHBDF2 gene. In humans, the canonical protein has a reported length of 856 amino acid residues and a mass of 96.7 kDa. Its subcellular localization is in the ER and cell membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Peptidase S54 protein family, it is reported to regulate ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Other names for this target antigen include rhomboid family member 2, rhomboid veinlet-like protein 5, rhomboid veinlet-like protein 6, and inactive rhomboid protein 2. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species. Some rhomboid 5 homolog 2 antibodies may have been used in research and have associated citations. ELISA, Western Blot, and Immunohistochemistry are common applications for these antibodies.