Anti-regulatory factor X6 antibodies are used for the immunodetection of the protein encoded by the RFX6 gene. In humans, the canonical protein has a reported length of 928 amino acid residues and a mass of 102.5 kDa. Its subcellular localization is in the nucleus. It is notably expressed in the pancreas. A member of the RFX protein family, it is known to be a transcription factor required to direct islet cell differentiation during endocrine pancreas development. The gene encoding this protein is implicated in Mitchell-Riley syndrome. Other names for this target antigen include DNA-binding protein RFX6 and regulatory factor X domain-containing protein 1. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some regulatory factor X6 antibodies may have been used in research and have associated citations. Immunohistochemistry is a widely used application for these antibodies. ELISA and Western Blot are also common applications.