Anti-AGO3 antibodies are used in the immunodetection of the protein argonaute RISC catalytic component 3. In humans, the canonical protein has a reported length of 860 amino acid residues and a mass of 97.4 kDa. Its subcellular localization is in the cytoplasm. Up to 2 different isoforms have been reported for this protein. A member of the Argonaute protein family, AGO3 is known to be required for RNA-mediated gene silencing (RNAi). Post-translational modifications have been described, including ubiquitination. Synonyms for this target antigen include argonaute 3, RISC catalytic component, eukaryotic translation initiation factor 2C, 3, hAgo3, and protein argonaute-3. AGO3 gene orthologs have been reported in the mouse, rat, frog and chicken species. A number of AGO3 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunocytochemistry, and Immunofluorescence are also common applications.