Anti-TNFRSF10B antibodies are used in the immunodetection of the protein TNF receptor superfamily member 10b. In humans, the canonical protein has a reported length of 440 amino acid residues and a mass of 47.9 kDa. Its subcellular localization is in the membrane. Up to 3 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. TNFRSF10B is a known receptor for the cytotoxic ligand TNFSF10/TRAIL. Post-translational modifications have been described, including glycosylation. The TNFRSF10B gene has been associated with the disease, Squamous cell carcinoma of the head and neck. Synonyms for this target antigen include DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, and CD262. TNFRSF10B gene orthologs have been reported in the mouse and chimpanzee species. Over 720 citations in the literature describe the use of TNFRSF10B antibodies in research. Flow Cytometry is a widely used application for these antibodies. ELISA and Western Blot are also common applications.