Anti-SHLD2 antibodies are used in the immunodetection of the protein shieldin complex subunit 2. In humans, the canonical protein has a reported length of 835 amino acid residues and a mass of 93.7 kDa. Its subcellular localization is in the nucleus. Up to 2 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the SHLD2 protein family, SHLD2 is a known component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). Synonyms for this target antigen include FAM35A1, RINN2, bA163M19.1, RINN1-REV7-interacting novel NHEJ regulator 2, family with sequence similarity 35 member A, and FAM35A. SHLD2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish and chicken species. Some SHLD2 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.