Anti-NAD(P)HX epimerase antibodies are used in the immunodetection of the protein encoded by the NAXE gene. In humans, the canonical protein has a reported length of 288 amino acid residues and a mass of 31.7 kDa. Its subcellular localization is in the mitochondria and is also secreted. Alternative splicing is reported to yield 2 different isoforms for this protein. It is widely expressed across many tissue types. A member of the NnrE/AIBP protein family, it is known to catalyze the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Post-translational modifications have been described, including phosphorylation. Other names for this target antigen include AI-BP, apoA-I binding protein, apolipoprotein A-I-binding protein, yjeF N-terminal domain-containing protein 1, yjeF_N1, and NAD(P)H-hydrate epimerase.