Anti-TAC1 antibodies are used in the immunodetection of the protein tachykinin precursor 1. In humans, the canonical protein has a reported length of 129 amino acid residues and a mass of 15 kDa. It has been described to be a secreted protein. Up to 4 different isoforms have been reported for this protein. It is notably expressed in the small intestine, rectum, hippocampus, duodenum, and cerebral cortex. A member of the Tachykinin protein family, TAC1 is known to be involved with cell to cell signaling and chemical synaptic transmission. Post-translational modifications have been described, including protein cleavage.
The TAC1 marker can be used to identify Eccentric Medium Spiny Neurons, Gray Matter MGE Interneurons, Cerebral Cortex MGE Interneurons, Cerebral Cortex Chandelier Neurons, and Hypothalamus Mammillary Body Neurons.* Synonyms for this target antigen include NK2, NKNA, NPK, TAC2, protachykinin-1, PPT, neurokinin 1, and Hs.2563. TAC1 gene orthologs have been reported in the mouse, rat, bovine, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4