Anti-OTULIN antibodies are used in the immunodetection of the protein OTU deubiquitinase with linear linkage specificity. In humans, the canonical protein has a reported length of 352 amino acid residues and a mass of 40.3 kDa. Its subcellular localization is in the cytoplasm. A member of a the Peptidase C65 protein family, OTULIN is a reported deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Post-translational modifications have been described, including ubiquitination, acetylation and phosphorylation. Synonyms for this target antigen include OTU domain-containing deubiquitinase with linear linkage specificity, deubiquitinating enzyme otulin, family with sequence similarity 105, member B, and ubiquitin thioesterase otulin.