Anti-NTNG1 antibodies are used in the immunodetection of the protein netrin G1. In humans, the canonical protein has a reported length of 539 amino acid residues and a mass of 60.5 kDa. Its subcellular localization is in the cell membrane. Up to 6 different isoforms have been reported for this protein. It is reported to be highly expressed in the thalamus, with very low expression, if any, in other tissues. NTNG1 is known to be involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Post-translational modifications have been described, including N-glycosylation.
The NTNG1 marker can be used to identify Thalamus Oligodendrocyte Precursor Cells, Hypothalamus Mammillary Body Neurons, and Podocytes.* Synonyms for this target antigen include NetG1, axon guidance molecule, laminet 1, and Lmnt1. NTNG1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of NTNG1 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.
*HuBMAP Human Reference Atlas v1.4