Anti-SPO11 antibodies are used in the immunodetection of the protein SPO11 initiator of meiotic double strand breaks. In humans, the canonical protein has a reported length of 396 amino acid residues and a mass of 44.5 kDa. Its subcellular localization is in the nucleus. Up to 2 different isoforms have been reported for this protein. It is reported to be highly expressed in the testis. A member of the TOP6A protein family, SPO11 is a known component of the topoisomerase 6 complex specifically required for meiotic recombination. Synonyms for this target antigen include SPATA43, TOPOVIA, TOPVIA, meiotic recombination protein SPO11, SPO11 meiotic protein covalently bound to DSB homolog, and CT35. SPO11 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some SPO11 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.