Anti-PAPPA2 antibodies are used in the immunodetection of the protein pappalysin 2. In humans, the canonical protein has a reported length of 1791 amino acid residues and a mass of 198.5 kDa. It has been described to be a secreted protein. Up to 2 different isoforms have been reported for this protein. It is noted to be expressed abundantly in the placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas. A member of the Peptidase M43B protein family, PAPPA2 is known to be involved with receptor-mediated signaling pathways and proteolysis. Post-translational modifications have been described, including glycosylation.
The PAPPA2 marker can be used to identify Amygdala Excitatory Neurons.* Synonyms for this target antigen include pregnancy-associated plasma preproprotein-A2, pregnancy-associated plasma protein E1, and placenta-specific 3. PAPPA2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of PAPPA2 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4