Anti-PORCN antibodies are used in the immunodetection of the protein porcupine O-acyltransferase. In humans, the canonical protein has a reported length of 461 amino acid residues and a mass of 52.3 kDa. Its subcellular localization is in the ER. Up to 5 different isoforms have been reported for this protein. It is notably expressed in the placenta, hippocampus, endometrium, caudate, and adrenal gland. A member of the Membrane-bound acyltransferase protein family, porcn is reported to be a Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins. Synonyms for this target antigen include porcupine homolog, probable protein-cysteine N-palmitoyltransferase porcupine, and protein-serine O-palmitoleoyltransferase porcupine. PORCN gene orthologs have been reported in the mouse, rat, bovine, frog and chimpanzee species. A number of porcn antibodies have been mentioned in research publications and have associated citations. These antibodies are most commonly used in Western Blot experiments, among other applications.