Anti-SP3 antibodies are used in the immunodetection of the protein Sp3 transcription factor. In humans, the canonical protein has a reported length of 781 amino acid residues and a mass of 81.9 kDa. Its subcellular localization is in the nucleus. It is ubiquitously expressed across many tissue types. A member of the Sp1 C2H2-type zinc-finger protein family, SP3 is reported to be a transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Post-translational modifications have been described, including sumoylation and acetylation. Synonyms for this target antigen include transcription factor Sp3, GC-binding transcription factor Sp3, specificity protein 3, and SPR2. SP3 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of SP3 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.