Anti-AVR antibodies are used in antigen-specific immunodetection in biological samples. The target AVR is a known alias name of the protein NLR family pyrin domain containing 6, encoded by the NLRP6 gene in humans. This 892-amino acid residue protein is known to act as the sensor component of the NLRP6 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to maturation and secretion of IL1B and IL18. It is localized to the cell membrane, nucleus, and cytoplasm of the cell and features ubiquitinated post-translational modifications. In terms of tissue expression, it is reported to be expressed in peripheral blood leukocytes, predominantly in granulocytes and, at lower levels, in CD4(+) and CD8(+) T-cells. Indicated applications for AVR antibodies listed below include ELISA, Western Blot, Immunocytochemistry, Immunofluorescence, and Immunohistochemistry.