5-Iodo-2'-deoxyuridine From Sigma Aldrich is Ideal for Radiosensitization

UNC Chapel Hill

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Company:

Sigma Aldrich

Product Name:

5-Iodo-2′-deoxyuridine

Catalog Number:

I7125

5-Iodo-2'-deoxyuridine (5-IUdR; IdUrd) is a pyrimidine analog (halogenated thymidine) that has antiviral activity against vaccinia virus (orthopoxviruses). IdUrd is used as a radiosensitizer in human cancer studies.

Experimental Design and Results Summary

Application

Cell culture

Starting Material

Cultured mammalian cells

Tips

I use concentration based on published data.

Results Summary

5-Iodo-2′-deoxyuridine prevents in vitro DNA viral replication. This is observed in herpesviruses and poxviruses It might possess teratogenic, tumor-promoting, mutagenic, and immunosuppressive properties.

DOI or PMID #

N/A

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Summary

The Good

Works well with all cell lines.

The Bad

Can't think of anything bad.

The Bottom Line

5-Iodo-2′-deoxyuridine, used in topical applications, and is effective against epithelial infections. I have used it on multiple cell lines.

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