R&D Systems
TGFBR1
MAB5871
N/A
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Browse Similar Products: TGF Beta Antibodies
TGF-β signaling is initiated by the binding of TGF-β to its serine and threonine kinase receptors, the type II (TβRII) and type I (TβRI) receptors on the cell membrane. Ligand binding leads to formation of the receptor heterocomplex, in which TβRII phosphorylates threonine and serine residues in the TTSGSGSG motif of TβRI and thus activates TβRI.
Western Blot
Culture samples
1:1000 dilution overnight incubation
1% BSA prepared in 1X TBST
1:10000 4% milk prepared in 1X TBST
None
ECL
TGF-β family, they have their own type I and type II receptors. Among the seven type I receptors, which are also called as ALKs, TβRI/ALK5 can mediate TGF-β signaling with the TGF-β type II receptor TβRII to activate Smad2/3 in universal cell types, while in endothelial cells ALK1 functions with TβRII to activate Smad1/5/8 for TGF-β signaling. In our results we found time dependent increased in ALK5 expression in TGFbeta stimulated cells.
Great
Perfect antibody for translocation.