Tocris
PD 184352
4237
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The role of ERK MAPK pathway was studied in the LPA induced pro-inflammatory phenotype in microglia. In this case cells were incubated for the indicated time points with LPA (1µM) in the presence or absence of PD98059 (10µM) or PD184352 (10µM).
ELISA, WB, Flow cytometry, Biochemical assays
Primary murine microglia
Nothing specific
The effect of PD1843452 was more prominent between the two MEK inhibitors in slightly decreasing the LPA induced expression of pp65.
N/A
Easy to use, reproducible results
None
A selective and orally active MEK inhibitor.