CD86 to Measure Dendritic Cell Activation

Tisch Cancer Institute
Icahn School of Medicine at Mount Sinai
Post-Doc

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Quality of Results

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Company:

BD Biosciences

Product Name:

Anti-human CD86 Alexa Fluor 700

Catalog Number:

561124

Browse Similar Products: CD86 Flow Cytometry Antibodies

Human peripheral dendritic cells were stimulated with pIC and activation was measured by CD86 staining. The antibody gives a good, dynamic signal.

Experimental Design and Results Summary

Applications

Flow Cytometry

Sample

Human PBMC

Primary Incubation

1 µL/test, RT, 15 min

Blocking Agent

Housemade blocking buffer containing normal sera

Secondary Incubation

N/A

Tertiary Incubation

N/A

Detection

LSR Fortessa

Results Summary

Human PBMC were stimulated with pIC overnight and activation on dendritic cells (CD11c+MHC-II+) was measured using anti-CD86 AF700. Blue histogram: unstimulated; orange histogram: pIC. The antibody is bright enough to be used at a 5x lower test size than recommended (1µL instead of 5 µL) and results in a dynamic signal.

DOI or PMID #

N/A

Additional Notes

N/A

Related Categories

Image Gallery

Summary

The Good

Dynamic signal

The Bad

Not as bright as some other colors (e.g., BV conjugates)

The Bottom Line

Very good antibody to measure dendritic cell activation, delivering a dynamic signal

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