Anti-MMP9 (Western Blot)

Anesthesiology
University of Wisconsin-Madison
Research Associate

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Company:

Antibodies Incorporated

Product Name:

Anti-Matrix Metalloproteinase 9

Catalog Number:

75-100

Browse Similar Products: MMP9 Western Blot Antibodies

This antibody was used in a study investigating the effects of N-glycosylation within Matrix Metalloproteinase-9 (MMP9) by characterizing the intracellular organelle trafficking of the N-glycoyslation mutants of MMP9. It has been published in Traffic in 2015 (Duellman et al., Functional Roles of N-Linked Glycosylation of Human Matrix Metalloproteinase 9, Traffic. 10, 1108-26). Anti-MMP9 was used to detect secreted MMP9 from rat macrophage cells (RAW264.7). Conditioned medium was stained for MMP9 to quantify the levels of secreted MMP9 in PMA stimulated cells using different secretion or N-glycosylation inhibitors.

Experimental Design and Results Summary

Applications

Western Blot

Sample

Conditioned media from PMA stimulated rat RAW264.7 cells in the absence or presence of different secretion or N-glycosylation inhibitors.

Primary Incubation

1:1000 in 2% milk incubated at 4C overnight

Blocking Agent

5% milk

Secondary Incubation

Anti-Mouse-HRP (1:5000) in 2% milk incubated for 1 hour at room temperature.

Tertiary Incubation

N/A

Detection

SuperSignal West Femto ECL Substrate (Thermo #34094)

Results Summary

Anti-MMP9 worked great in numerous applications and with different sample preparations including endogenous or exogenous protein detection.

Additional Notes

Reactivity against human, rat, and mouse.

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Summary

The Good

This antibody has worked great for western blotting purposes and is sold at an extremely reasonable price compared to other commercial vendors.

The Bad

None to report.

The Bottom Line

I would strongly recommend this antibody to other investigators studying MMP9.

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