Gel Extraction Made Easy

University of Montana
BMED
Technician

Overall

Quality of Results

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Company:

Omega Bio-Tek

Product Name:

E.Z.N.A. Gel Extraction Kit

Catalog Number:

D2501-01

Standard cloning and sub-cloning procedures will oftentimes depend upon digesting and purifying either vector or gene of interest DNA. There are many kits available to perform this purification. Most of these kits have anion exchange at the center of their protocols with each company developing a proprietary buffer and pH conditions. For cost savings and a straightforward protocol the Omega Bio-Tek Gel Extraction Kit delivers clean reproducible results at an affordable price.

Experimental Design and Results Summary

Application

DNA purification

Starting Material

Agarose bound DNA, restriction digests

Protocol Overview

The protcol is based off standard low melt gel protocols. Briefly, the sample is excised from the gel and weighed. A chaotropic salt buffer is then added at a specified ratio and the entire sample is heated to 60°C for 5-10min. The melted sample is then added to a spin column or onto the luer lock of a vacuum manifold. The sample is bound to the column, washed several times and then removed from the column with elution buffer.

Tips

Have the heat block equlibrated prior to start of the protocol. Add ethanol to wash buffer prior to starting.

Results Summary

DNA with a high purity is usable in downstream applications from sub cloning to PCR.

Additional Notes

None

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Summary

The Good

Quick, easy and inexpensive.

The Bad

Plastic waste

The Bottom Line

An affordable kit for the purification of DNA from either agarose gel on enzymatic reactions.

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