Adeno-associated viruses are one of the most well known viral delivery systems and are regularly used in gene therapy applications. Unfortunately, production of large quantities of AAV tends to be complicated and costly.
Boston University School of Medicine (BUSM) researchers reported yesterday in Scientific Reports that they have developed an advanced protocol to produce large quantities of AAVs.
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The BUSM technique bypasses developmental effects that can arise from conventional gene manipulation in animals, while saving time, reducing the numbers of animals used in research and eventually research cost.
"Our protocol helps to produce AAVs efficiently and economically in regular laboratories so that researchers can easily conduct a pre-clinical trials for gene therapy," explained co-corresponding author Markus Bachschmid, Ph.D.