How the Nose Adapts to Smells

The findings from a study published in eLife today contribute to our understanding of how and why the mammalian nose adapts to smells. They could also help us understand how decreases in the number of neurons in the nose over a lifetime affect our sense of smell as we age.

The nose senses smells when molecules drift from nearby objects and activate receptor neurons. In the noses of mice, there are about 10 million receptor neurons, which are split into over 1,000 types that each respond differently depending on what molecules they detect. Each receptor neuron is activated by many different smells, and each smell activates many different types of receptors. This means that to understand a smell, the brain needs to read the overall pattern of activation, or “coding”, across the different receptor types.

"Some types of receptor neurons in the nose are used more often than others, depending on the animal's species," says lead author Tiberiu Tesileanu, from the Center for Computational Biology at the Flatiron Institute. "Recent experiments have also shown that the way different receptor types are used can change when animals are exposed to different smells. In our current study, we set out to explain these findings and build a model that can predict the observed biases in how receptors are used."

Tesileanu and his teambuilt a model for the distribution of receptor types. The model assumes that the nose can adapt itself to tell the brain, in the most efficient way possible, about common smells in our surroundings. "For instance, the receptor types activated by variable smells are important because they convey a lot of information to the brain about this variability, and are more abundant in the nose because of this," Tesileanu explains. "To our knowledge, this is the first time that such 'efficient coding' ideas have been applied to explain patterns in the use of receptor neurons by the nose."