Researchers have developed a novel drug delivery method for repairing cells deep within the ear. According to the study, published today in Bioconjugate Chemistry, this method can deliver drugs into the ear without it being swept away by inner ear fluid, something that has not been possible in the past. If effective, this approach could restore hearing for millions of elderly people and others who suffer hearing loss.
The drug delivery method developed by the USC researchers targets the cochlea, a structure that houses sensitive cells that convey sound to the brain. When exposed to loud noises over time, the hair-like sensory cells and bundles of neurons break down, causing hearing loss.
The treatment designed by the researchers consists of a molecule that combines 7,8-dihydroxyflavone, which mimics a protein critical for development and function of the nervous system, and bisphosphonate, a drug that sticks to the bones. When tested in animal tissue, the combination treatment was successful in regenerating synapses in mouse ear tissue, leading to repair of the hair cells and neurons essential to hearing.
While there is still a way to go before this gets to clinical trial stages, the researchers are hopeful this technique may someday offer a way to help those suffering from hearing loss. The team is currently working towards the next phase in their study, which will be to test the treatment technique in live animals.
Image: Infographic of hearing loss treatment developed by USC scientists. Image courtesy of USC.