Fig 1: K5 prevents bFGF internalization and inhibits FGFR1 phosphorylation. (A) Chemical structure of K5. (B) Quantification of the concentration of bFGF in cell culture medium of H5V cells incubated with increasing doses of K5 and 5 ng/ml of bFGF (n = 3 technical replicates). (C) Concentration of phosphorylated FGFR1 in HUVECs treated with two different concentration of K5 (n = 3 technical replicates). Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001. ****p < 0.0001; by 2-sided Student t test.