Fig 1: Blood cells and inflammation marker differ in dogs with or without canine atopic dermatitis CAD. Boxplot comparing (A) Red blood cell parameters: mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC); (B) White blood cells: white blood cells, total neutrophils and monocyte numbers; and (C) Humoral parameters: total protein, albumin and CRP levels in treated dogs with CAD or healthy control dogs. For statistical analyses, groups were tested for normality with Anderson-Darling-test, before parameters were compared with unpaired t-test (MCV MCH, white blood cells, neutrophils, total protein and albumin) or Mann-Whitney U test (monocytes) and Kolmogorov-Smirnov test (CRP). p < 0.5, **** p < 0.0001
Fig 2: Correlation and regression analyses of serum iron in dogs with CAD or considered healthy. A. Spearman correlation of serum iron are in CAD-patients negatively associate with ferritin, MCV, PCV, albumin and CRP, and positive with ceruloplasmin, while in the healthy cohort, serum iron was negatively associated with hepcidin and positive with total protein. B. Linear regression analysis (with transformed data to reach parametric distribution) to inversed serum iron showed that serum iron was significantly negatively dependent with PCV and albumin, whereas a positive dependency was seen with white blood cell number and neutrophils in dogs with CAD. In contrast in the healthy cohort, only hepcidin showed a negatively dependency with serum iron-levels. P < 0.05 is considered significant
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