FLIPR® Calcium & Calcium 3, 4, & 5 Assay Kits from Molecular Devices

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ItemFLIPR® Calcium & Calcium 3, 4, & 5 Assay Kits
CompanyMolecular Devices
Price Supplier Page View Company Product Page
Catalog NumberFLIPR

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Molecular Devices

3860 N First Street

San Jose, California 95134

United States

Phone: 408-747-1700

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Website: www.moleculardevices.com

(1) Positive allosteric modulator activity of ginsenosides is restricted to P2X7 and P2X4 receptorsPurinergic SignalMay 23, 2026Elizabeth Allum, Leanne Stokesmultiple P2X receptor responses have been measured using a single assay for screening purposes. The FLIPR membrane potential assay was easy to use and has potential value in future screening programs. We used

(2) Discovery and Characterization of a Nonacidic Small-Molecule Inhibitor of the Sodium-Coupled Dicarboxylate Transporter NaCTJournal of Medicinal ChemistryMay 14, 2026Andrew Quigley, Jörg T. Kley, Alexander Pautsch, Stefan G. Kauschke, Amy Chu-Antypas, Annamaria Tessitore, Claire Strain-Damerell, Leela Shrestha, Dieter Wiedenmayer, Nicola A. Burgess-Brown, et al.spectrometer (Agilent Technologies Inc., Palo Alto, CA, USA). Membrane Potential Assays Using the FLIPR Membrane Potential Kit for measuring membrane potential (Molecular Devices, catalog no. R-8123), compounds

(3) Neurokinin‐1 receptor activation protects against cardiac fibrosis, inflammation and diastolic dysfunction in type 2 diabetic miceBritish Journal of PharmacologyApril 25, 2026Alexander Widiapradja, Heather Connery, Brody J. Helmick, Kallie J. Schafner, Vamsi Manchikalapudi, Hannah Horvath, Sophia Gugino, Tamas Kriska, Anja Herrnreiter, Evan DeVallance, et al.intracellular calcium [Ca2+]i mobilisation assay was performed using a fluorescence imaging plate reader (FLIPR, Molecular Devices) as previously described (Kriska et al., 2022; Park et al., 2018). In brief, human

(4) The Discovery of RGH-706, a Highly Efficacious MCH1 Receptor Antagonist, for the Treatment of Obesity and Insatiable HungerJournal of Medicinal ChemistryApril 23, 2026Gyula Beke, András Boros, György M. Keserű, Balázs Krámos, Krisztina Katalin Szalai, Anikó Gere, Mónika Vastag, Márta Thán, Balázs Varga, Ottilia Balázs, et al.of measurement, the culture medium was removed from the cells, and a fluorescent Ca2+-sensitive dye (FLIPR calcium 5 kit, Molecular Devices R8186) was added to the cells at a 4× dilution compared to the recommended

(5) Monoclonal antibody inhibition of PAR2 reduces phenotype severity and pain in murine inflammatory bowel diseasePain RepApril 20, 2026Anne Ritoux, Laura J. Grundy, Pravallika Manjappa, Luke W. Paine, Jessica Neisen, John E. Linley, Ewan St. John SmithKit (ThermoFisher, Waltham, MA). Ca2+ responses measured using the fluorescence imaging plate reader (FLIPR) Tetra system (Molecular Devices, San Jose, CA); excitation and emission wavelengths: 470 to 495 nm

(6) Monoclonal antibody inhibition of PAR2 reduces phenotype severity and pain in murine inflammatory bowel diseasePain RepApril 20, 2026Anne Ritoux, Laura J. Grundy, Pravallika Manjappa, Luke W. Paine, Jessica Neisen, John E. Linley, Ewan St. John SmithKit (ThermoFisher, Waltham, MA). Ca2+ responses measured using the fluorescence imaging plate reader (FLIPR) Tetra system (Molecular Devices, San Jose, CA); excitation and emission wavelengths: 470 to 495 nm

(7) Deletion of Mitochondrial Calcium Uniporter Enhances Calcium Signals by Slowing Calcium Clearance and Triggers Adaptive Transcriptomic RemodelingJournal of Biological ChemistryApril 17, 2026Rajesh Bhardwaj, Abdull J. Massri, Gary S. Bird, Anant B. ParekhCa2+ indicator were excited using a 470 to 495 nm LED module of the Fluorometric Imaging Plate Reader (FLIPR Tetra; Molecular Devices), and the resulting fluorescence emission was collected through a 515 to 575

(8) Quantitative Estimates of Inter-individual Variability for New Approach Methodologies-Based Systemic Safety Toolbox Using a Population-Based Human in Vitro ModelToxicological SciencesApril 7, 2026Ibrahim Alshammari, Lucie C Ford, Han-Hsuan D Tsai, Hsing-Chieh Lin, Chander K Negi, Allison N Dickey, Fred A Wright, Alistair M Middleton, Maria T Baltazar, Joe Reynolds, et al.a “working plate” into an assay plate with cells was done using an automated liquid handler in the FLIPR Tetra (Molecular Devices, San Jose, CA, United States). Five microliters from each well in a “working

(9) Investigation of Radiolabeled KISS1R Ligands as Promising Tools for Diagnosis and Treatment of Triple-Negative Breast CancerMolecular PharmaceuticsApril 6, 2026Harun Taş, Martin Schäfer, Aneeba Shuja-Uddin, Ulrike Bauder-Wüst, Luciana Kovacs Dos Santos, Lisa Bartnitzky, Felix Oden, Magdalena Platzk, Tim König, Patrick Leopold Rüther, et al.diluted in 2 mM Ca-Tyrode in 4-fold concentration. 10 μL hereof was added to the cell plates in the FLIPR Tetra (Molecular Devices), and luminescence was measured immediately for 1 min. Every concentration

(10) Bothrops venom variation drives niche-specific pharmacology through Ca2+ signalling and membrane damageFrontiers in PharmacologyMarch 31, 2026Lachlan A. Bourke, Julien Slagboom, Matthew A. Waller, G. Gregory Neely, Jeroen Kool, Fernanda C. Cardosowas used to extract raw trace data and kinetic reductions (area under the curve and Max-Min) from the FLIPR assays. The ratiometric (DNA response/[Ca2+]i response) Max-Min was also extracted. Raw trace data were

(11) A luminescent calcium biosensor enabling endpoint measurement of GPCR-mediated calcium signalingCommunications BiologyMarch 29, 2026Kosuke Doi, Ryoji Kise, Kota Shimizume, Masataka Yanagawa, Asuka Inouewindow after agonist (or vehicle) addition. The Z′-factor was calculated as previously described25. FLIPR calcium assay The FLIPR calcium 6 assay kit (Molecular Devices, USA) was dissolved at 0.6 mg/mL in

(12) Voltage-gated calcium channels as key regulators of neuronal differentiation in the immortalized dorsal root ganglion neuronal cell line F11Scientific ReportsMarch 23, 2026D. López, J. Brea, M. Barro, M. I. Loza, A. L. Martínez72 h, the medium was removed and replaced with 25 µL of fresh medium, then incubated with 25 µL of FLIPR Calcium-6 dye (R8190; Molecular Devices, Sunnyvale, CA) diluted in HBSS (Hank’s Balanced Salt Solution;

(13) Functional and structural basis of a negative allostery within GABAB hetero-tetramersNature CommunicationsMarch 20, 2026Cangsong Shen, Hongyang Ding, Shenlan Zhang, Chanjuan Xu, Binqian Zou, Suyu Ji, Yi-Ru Liu, Yizhong Li, Rui Zhou, Jiayin Liang, et al.signals (excitation 485 nm, emission 525 nm) were measured by using the fluorescence microplate reader FLIPR Tetra (Molecular Devices, Sunnyvale, CA, USA) at sampling intervals of 1 s for 120 s. The response of

(14) Agonist-specific FPR1 conformational change prevents receptor recycling and promotes targeted protein degradationActa Pharmaceutica Sinica BMarch 15, 2026Junlin Wang, Qiwen Liao, Geng Chen, Yixin Chang, Hong Nie, Jiahong Lu, Richard D. Yeand 4-nitrophenyl N-acetyl-β-d-glucosaminide were obtained from Sigma–Aldrich, St. Louis, MO, USA. FLIPR calcium 5 reagent was purchased from Molecular Devices, San Jose, CA, USA. Coelenterazine H was purchased

(15) The scramblase anoctamin 9 controls the immune response in lymphocytesCell Mol Life SciMarch 4, 2026Rainer Schreiber, Jiraporn Ousingsawat, Karl KunzelmannMolecular Devices, Ismaning, Germany) in ringer solution (1:5 dilution) at room temperature for 15 to 30 min. FLIPR was exited with 485 nm and emission was detected between 515 and 560 nm. Control of the experiment,

(16) Investigating the impact and mechanism of Licochalcone B derivative CTG12 on NLRP3 inflammasomeCell Communication and SignalingFebruary 18, 2026Shuyi Bian, Zhi-E Fang, Lichen Wang, Jiayi Wang, Ming Dong, Nan Yang, Jiabo Wang, Ling Li, Guang Xustimulated with ATP for 45 min, with or without CTG12. ATP-triggered Ca2⁺ fluxes were recorded using the FLIPR Tetra® system (Molecular Devices, USA). Cellular thermal shift assay (CETSA) THP1 cells were incubated

(17) Development of activators for SERCA2a for heart failure treatmentsEuropean Journal of Medicinal ChemistryFebruary 5, 2026Marzena Brinkmann, Tsung-Yun (Kent) Wong, Osha Roopnarine, Samantha L. Yuen, Kaja Berg, Razvan L. Cornea, Robyn T. Rebbeck, David D. Thomas, Courtney C. Aldrichmonitored by observing the decrease in 485-nm excited fluorescence of Fluo-4 at 520 nm for 15 min using a FLIPR Tetra (Molecular Devices, San Jose, CA). Similar controls as in the ATPase activity assays were also

(18) The selectivity implications of docking libraries with greater and lesser similarities to bio-like moleculesbioRxivFebruary 4, 2026Brendan W Hall, Kensuke Sakamoto, Xi-Ping Huang, John J Irwin, Brian K Shoichet, Bryan L Rothsource plate for additions yielding a 1x final concentration (3 μM). Fluorescence was recorded on a FLIPR-Tetra (Molecular Devices): a 10 s baseline (1 read/s) was followed by 120 s post-addition acquisition

(19) Assessing Aβ-independent effects of Module 42 on immune function in vitroAlzheimer's & dementia : the journal of the Alzheimer's AssociationFebruary 1, 2026Ajith I, Bakshi S, Mead E, Gileadi O, Katis VL, Brennan PE, Emory‐Sage‐SGC‐Jax TREAT‐AD Center, Gospodinova KO.(6 µM final concentration) was used as a positive control. Calcium responses were measured using a FLIPR Tetra system (Molecular Devices). Baseline fluorescence was recorded for 1 min using 470‐ to 495‐nm

(20) Clonazepam activates the transient receptor potential melastatin 8 (TRPM8) ion channelbioRxivJanuary 28, 2026Logan Elkin, Evgeny G. Chulkov, Jonathan Enders, Anthony D. Menzel, Sang-Kyu Park, Cheryl L. Stucky, Jonathan S. Marchantsupplemented with reporter dye (10 μl) added prior to incubation (37 C, 40 mins). Plates were then placed in a FLIPR (Molecular Devices, serial no: FX01138), and fluorescence monitored (488nm/510–570nm) every second prior

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FLIPR® Calcium & Calcium 3, 4, & 5 Assay Kits from Molecular Devices

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Molecular Devices

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FLIPR® Calcium & Calcium 3, 4, & 5 Assay Kits from Molecular Devices

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