Fig 1: ELISA validation of three serum biomarkers using an independent cohort and their correlation with clinical indices. (A–C) A cohort of 80 serum samples: 30 healthy controls (HC, green) and 50 patients with lupus nephritis (LN, red) were tested by ELISA for the levels of ICAM2, TIMP1 and THBS1. (D) The discriminatory abilities of the three serum markers were assessed in distinguishing patients with LN from HCs using receiver operating characteristic (ROC) curve analysis. (E–K) The correlation of ELISA-assayed serum ICAM2 levels with clinical indices in LN. r denotes Spearman’s correlation coefficient. ****p<0.0001. AUC, area under the curve.
Fig 2: Plasma TSP-1 and uric acid levels stratified by etiology and proteinuria events.
Fig 3: Serum TSP1 and urine protein levels in patients with and without proteinuria events among nephrotic syndrome.
Fig 4: ROC curve of plasma TSP-1 for predicting proteinuria events in non-CAKUT pediatric CKD patients.
Fig 5: Fisher’s z-test reveals differences in TSP-1 correlations with clinical parameters between CAKUT and non-CAKUT groups.
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