Fig 1: Kinetic inhibition of fibronectin 1 (FN1) in HUVECKi2. Relative amount of fibronectin is indicated at each time (h) after treatment. HUVECKi2 was treated with 0.5 μmol/L GO‐Y078 (closed rectangle), 1.0 μmol/L GO‐Y078 (closed triangle), 1.0 μmol/L sorafenib (closed circle), and 1.0 μmol/L sunitinib (open rectangle). Mock is indicated by open circle. *P < .05, **P < .001
Fig 2: Knockdown effect of fibronectin 1 (FN1) on the growth of HUVECKi2. A, Efficacies of Si‐oligos to FN1 mRNA in the attached HUVECKi2. B, Effects on the growth of the attached HUVECKi2 treated with FN1‐Si‐oligo (open circle), control‐Si‐oligo (closed rectangle), and without Si‐oligo (closed circle). C, Efficacies of Si‐oligos to FN1 mRNA in the suspended HUVECKi2. D, Effects of the growth of the suspended HUVECKi2 treated with the FN1‐Si‐oligo (open circle), control‐Si‐oligo (closed rectangle), and without Si‐oligo (closed circle)
Fig 3: Dose‐dependent inhibition of fibronectin 1 (FN1) by GO‐Y078. Relative expression values of the Mock (indicated by closed bars) and those of the treated levels with 0.5 μmol/L (shaded bars) and 1.0 μmol/L GO‐Y078 (open bars) are indicated. *P < .001, **P < .05. ***no significance
Fig 4: RT‐PCR of the candidate transcripts in HUVECKi2 affected by GO‐Y078. Relative expression values of the basal levels (closed bars) and those of the treated levels with 0.5 μmol/L GO‐Y078 (shaded bars) are indicated. A, fibronectin 1 (FN1); B, other candidates
Supplier Page from Abcam for Human Fibronectin ELISA Kit