Description
Throughout the circulatory life of the red cell, glycohemoglobin is formed continuously by the addition of glucose to the N-terminal of the hemoglobin beta-chain. This process, which is non-enzymatic, reflects the average exposure of hemoglobin to glucose over an extended period. In a classical study, Trivelli et al1 showed glycohemoglobin in diabetic subjects to be elevated 2-3 fold over the levels found in normal individuals. Several investigators have recommended that glycohemoglobin serve as an indicator of metabolic control for diabetic, since glycohemoglobin levels approach normal values for diabetics in metabolic control