Description
Kinetic and endpoint methods for the quantitative determination of creatinine in serum. Creatinine, an anhydride of creatine, is a waste product formed by the spontaneous dehydration of kidneys. Most of the creatinine is found in muscle tissue where it is present as creatine phosphate and serves as a high energy storage reservoir for conversion to ATP. In-dependent of diet, serum creatinine concentrations depends almost entirely upon its excretion rate by the kidneys. For this reason, its elevation is highly specific for kidney diseases.