Fig 1: Comparison of a spinal cord (SC) lesion in intraspinal (i.s.) versus intracerebral (i.c.) TMEV-infected mice at 14 or 56 days post infection (dpi), respectively. Data are given for each spinal cord (SC) segment separately including numbers of immunolabeled cells for CD107b (microglia/macrophages), CD3 (T lymphocytes), CD45R (B lymphocytes), TMEV (Theiler’s murine encephalomyelitis virus) and periaxin (Schwann cells) and immunolabeled axons for ß-APP (beta-amyloid precursor protein; axonal damage). Furthermore, MBP (myelin basic protein) was used for the quantification of demyelination and data are presented as percentage of total white matter area. Data are presented as box-and-whisker plots showing median and quartiles. Significant differences between the i.s. and i.c. infection models as detected by a Mann–Whitney U-test are indicated by asterisks (* p < 0.05).