InVivoMab anti-human/monkey CD20 BE0276-R100mg from Bio X Cell

Description

Bio X Cell InVivoMAb anti-human/monkey CD20 Monoclonal Antibody has the following reported applications: in vivo B cell depletion in hCD20 Tg mice, Immunohistochemistry (frozen), Immunoprecipitation, Flow cytometry. It features greater than 95% purity, ultra-low endotoxin levels, and are preservative, stabilizer, and carrier protein-free

Product Specs
ItemInVivoMab anti-human/monkey CD20
CompanyBio X Cell
Price $4,651.50Supplier Page View Company Product Page
Catalog NumberBE0276-R100mg
Quantity100 mg
Applicationsin vivo B cell depletion in hCD20 Tg mice, Immunohistochemistry (frozen), Immunoprecipitation, Flow cytometry
ConcentrationLot specific,typically between 4-11 mg/ml
Conjugate/TagUnconjugated
FormatPBS, pH 7.0, Contains no stabilizers or preservatives, Liquid
Purity≥95%, Determined by SDS-PAGE
ReactivityHuman, Monkey
TargetCD20
IsotypeIgG2b, κ
Clone2H7
Hostmouse
Antibody TypePrimary Antibody
ImmunogenHuman tonsillar B cells
NCBI Full Gene Namemembrane spanning 4-domains A1
NCBI Gene AliasesB1, Bp35, CD20, CVID5, FMC7, LEU-16, S7
ClonalityMonoclonal
Research AreaCancer Biology, Immunology, CD Markers
StorageThe antibody solution should be stored at the stock concentration at 4°C. Do not freeze
Molecular Weight150 kDa
ModificationsNo
OriginUnited States

Specifications/Features

Endotoxin: ≤1EU/mg (≤0.001EU/µg), Determined by LAL gel clotting assay

Quantities Available: 1mg, 5mg, 25mg,50mg, 100mg, Additional Custom Sizing Available on bioxcell.com

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Bio X Cell

39 Labombard Rd

Lebanon, NH 03766

United States

Phone: 1-866-787-3444

Email: customerservice@bioxcell.com

Company Profile

Website: bioxcell.com

(1) Proinflammatory GM-CSF-producing B cells in multiple sclerosis and B cell depletion therapyScience translational medicineOctober 21, 2015Li R, Rezk A, Miyazaki Y, Hilgenberg E, Touil H, Shen P, Moore CS, Michel L, Althekair F, Rajasekharan S, et al.

(2) Combination treatment with anti-CD20 and oral anti-CD3 prevents and reverses autoimmune diabetesDiabetesAugust 1, 2013Hu C, Ding H, Zhang X, Wong FS, Wen L.

(3) The dual effects of B cell depletion on antigen-specific T cells in BDC2.5NOD miceJournal of immunology (Baltimore, Md. : 1950)May 15, 2012Xiang Y, Peng J, Tai N, Hu C, Zhou Z, Wong FS, Wen L.

(4) B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in agingBloodMarch 17, 2011Keren Z, Naor S, Nussbaum S, Golan K, Itkin T, Sasaki Y, Schmidt-Supprian M, Lapidot T, Melamed D.

(5) B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunityAnnals of neurologySeptember 1, 2010Weber MS, Prod'homme T, Patarroyo JC, Molnarfi N, Karnezis T, Lehmann-Horn K, Danilenko DM, Eastham-Anderson J, Slavin AJ, Linington C, et al.

(6) Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammationPediatric researchJuly 1, 2004Mack CL, Tucker RM, Sokol RJ, Karrer FM, Kotzin BL, Whitington PF, Miller SD.

(7) Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal antibodies is defined by additional requirements imposed by both amino acid sequence and quaternary structureBloodMay 1, 2002Polyak MJ, Deans JP.

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